Absorption and sedative effects of diazepam after oral administration and intramuscular administration into the vastus lateralis muscle and the deltoid muscle

36Citations
Citations of this article
9Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Summary: The absorption of diazepam 10 mg after oral administration and intramuscular administration into the vastus lateralis muscle or the deltoid muscle was compared in a double-blind cross-over study in eight healthy subjects. Serum diazepam concentrations were measured, and the presence of tiredness was noted 20, 40, 60, 90 and 150 min after the drug administration. Peak concentrations in serum were 209±49, 152±60 and 143±62 ng/ml (means ±SD) at 90, 60 and 60 min after oral, shoulder and thigh administration respectively. Absorption was more rapid after intramuscular than after oral administration, serum mean diazepam concentrations at 20 min after oral administration being only 26% of those after shoulder administration. The rapid rate of absorption from the shoulder was associated with a more rapid feeling of tiredness and a greater sedative effect than after oral or thigh administration. There was no evidence that diazepam induced its own metabolism after one or two administrations. The results suggest that, if rapid pre-anaesthetic medication with diazepam is needed, shoulder administration might be superior to oral or thigh administration. © 1975 Macmillan Journals Ltd.

Cite

CITATION STYLE

APA

Korttila, K., & Linnoila, M. (1975). Absorption and sedative effects of diazepam after oral administration and intramuscular administration into the vastus lateralis muscle and the deltoid muscle. British Journal of Anaesthesia, 47(8), 857–862. https://doi.org/10.1093/bja/47.8.857

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free