Synthesis, characterization and antibacterial study of tripodal tris-(N-benzoylthioureido)ethylamine

Abstract

A new tripodal tris-(N-benzoylthiouredoethyl)amine has been successfully synthesized and characterized by spectroscopic technique such as FTIR, ESI MS, 1 H and 13 C NMR. The microanalysis data is in a good agreement with the expected molecular formula. The 1 H NMR chemical shift for both amide and thioamide proton are at lower field than their normal value indicates the presence of the hydrogen bond between the carbonyl oxygen atom and thioamide hydrogen. This is possible when the benzoyl group adopt a trans configuration againts thione group along the C-N bond. The compound has been tested for antibacterial activity against three selected bacteria namely Staphylococcus aureus, Proteus vulgaris and Pseudomanas aeroginosa but there is no significant activities observed.