Purpose: Our previous study found that white adipose stem cells (W-ASCs) derived from abdominal and femoral sulcus white adipose stem cells (ASCs) have antiaging and agerelated obesity effects. Whether interscapular brown adipose stem cells (B-ASCs) have the same effect has not been reported. The study objective was to compare the effects of ASCs from different tissues on aging and aging-related obesity. Patients and Methods: C57BL/6J mice at 22 months of age were transplanted with either B-ASCs or W-ASCs from young mice at 2 months of age. Changes in body weight, biochemistry, cytokines, hormone secretion, cell senescence, lipid metabolism, and ASC function were assessed after transplanted 1 month. Results: W-ASCs were superior to B-ASCs as aging and age-related obesity indicators, based on change in body weight, organ weight, antioxidant and anti-inflammatory activity, lipid metabolism, and liver and kidney function. Conclusion: Difference in the tissue source was reflected by the heterogeneity of antiaging and age-related obesity effects of transplanted ASCs. Based on the study results, we recommend W-ASCs over B-ASCs in aging and age-related obesity applications.
CITATION STYLE
Zhu, Y., Wang, T., He, S., Pu, S., Zhao, H., Zhou, Z., & Wu, Q. (2021). Comparison of antiobesity effects of adipose-derived stromal/stem cells from different sources in a natural aging model. Diabetes, Metabolic Syndrome and Obesity, 14, 4535–4546. https://doi.org/10.2147/DMSO.S334044
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