Plant VDAC Permeability: Molecular Basis and Role in Oxidative Stress

Abstract

This book covers recent advances in the study of structure, function, and regulation of metabolite, protein and ion translocating channels, and transporters in mitochondria. A wide array of cutting-edge methods are covered, ranging from electrophysiology and cell biology to bioinformatics, as well as structural, systems, and computational biology. At last, the molecular identity of two important channels in the mitochondrial inner membrane, the mitochondrial calcium uniporter and the mitochondrial permeability transition pore have been established. After years of work on the physiology and structure of VDAC channels in the mitochondrial outer membrane, there have been multiple discoveries on VDAC permeation and regulation by cytosolic proteins. Recent breakthroughs in structural studies of the mitochondrial cholesterol translocator reveal a set of novel unexpected features and provide essential clues for defining therapeutic strategies. Molecular Basis for Mitochondrial Signaling covers these and many more recent studies of mitochondria function, their communication with other organelles, and their critical roles in development, aging, and in a plethora of stressful or degenerative events. Authored by leading researchers in the field, this volume will be an indispensable reference resource for graduate students and academics working in related areas of biophysics and cell biology as well as for professionals within industry. Part I: Mitochondrial Calcium Signaling. Mitochondrial Ca2+ Handling and Behind: The Importance of Being in Contact with Other Organelles / Riccardo Filadi, Pierre Theurey, Alice Rossi, Chiara Fedeli, and Paola Pizzo -- Molecular Players of Mitochondrial Calcium Signaling: Similarities and Different Aspects in Various Organisms / Vanessa Checchetto, Diego De Stefani, Anna Raffaello, Rosario Rizzuto, and Ildiko Szabo -- PART II. The mitochondrial permeability transition pore: structure and function. The Mitochondrial Permeability Transition Pore: Molecular Structure and Function in Health and Disease / Elizabeth A. Jonas, George A. Porter Jr., Gisela Beutner, Nelli Mnatsakanyan, Han-A. Park, Nikita Mehta, Rongmin Chen, and Kambiz N. Alavian -- Mitochondrial calcium uptake in activation of the permeability transition core and cell death / Maria E. Solesio and Evgeny V. Pavlov -- PART III. Mitochondrial outer membrane transport systems: structure, function, and physiological implications. Voltage-dependent anion channels and tubulin: bioenergetic controllers in cancer cells / Eduardo N. Maldonado, David N. DeHart, and John J. Lemasters -- An assessment of how VDAC structures have impacted our understanding of their function / Lucie Bergodoll, Michael Grabe, and Jeff Abramson -- Plant VDAC permeability: molecular bases and role in oxidative stress / Fabrice Homblé, Hana Kmita, Hayet Saidani, and Marc Léonetti -- Lipids in regulation of the mitochondrial outer membrane permeability, bioenergetics, and metabolism / Tatiana K. Rostovtseva, David P. Hoogerheide, Amandine Rovini, and Sergey M. Bezrukov -- The mitochondrial outer membrane potential as an electrical feedback control of cell energy metabolism / Victor V. Lemeshko -- PART IV. Mitochondria and cellular signaling network. New insights on the regulation of programmed cell death by Bcl-2 family proteins at the mitochondria: physiological and pathophysiological implications / Laurent Dejean and Stéphen Manon -- The 18 kDa translocator protein (TSPO): cholesterol trafficking and the biology of a prognostic and therapeutic mitochondrial target / Michele Frison, Anna Katherina Mallach, Emma Kennedy, and Michelangelo Campanella -- Protein import channels in the crossroads of mitochondrial function / Ma Su Su Aung, Ruth Hartke, Stephen Madamba, Oygul Mirzalieva, and Pablo M. Peixoto -- Substrate selection and its impact on mitochondrial respiration and redox / Sonia Cortassa, Steven J. Sollott, and Miguel A. Aon.