The deubiquitinase USP54 is overexpressed in colorectal cancer stem cells and promotes intestinal tumorigenesis

30Citations
Citations of this article
35Readers
Mendeley users who have this article in their library.

Abstract

Ubiquitin-Specific Proteases (USPs) are deubiquitinating enzymes frequently deregulated in human malignancies. Here, we show that USP54 is overexpressed in intestinal stem cells and demonstrate that its downregulation in colorectal carcinoma cells impedes tumorigenesis. We have generated mutant mice deficient for this deubiquitinase, which are viable and fertile, and protected against chemicallyinduced colorectal carcinoma. Furthermore, we show that USP54 is upregulated in human colon cancer and associates with poor prognosis. In agreement with these results, Usp54 downregulation in mouse melanoma cells inhibits lung metastasis formation. Collectively, this work has uncovered the pro-tumorigenic properties of USP54, highlighting the importance of deubiquitinating enzymes as promising targets for the development of specific anti-cancer therapies.

References Powered by Scopus

Breaking the chains: Structure and function of the deubiquitinases

1709Citations
N/AReaders
Get full text

Online survival analysis software to assess the prognostic value of biomarkers using transcriptomic data in non-small-cell lung cancer

1399Citations
N/AReaders
Get full text

Targeting proteases: Successes, failures and future prospects

1147Citations
N/AReaders
Get full text

Cited by Powered by Scopus

The role of ubiquitination and deubiquitination in tumor invasion and metastasis

102Citations
N/AReaders
Get full text

Primary Cilia as Signaling Hubs in Health and Disease

67Citations
N/AReaders
Get full text

Functional analysis of deubiquitylating enzymes in tumorigenesis and development

59Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Fraile, J. M., Campos-Iglesias, D., Rodríguez, F., Español, Y., & Freije, J. M. P. (2016). The deubiquitinase USP54 is overexpressed in colorectal cancer stem cells and promotes intestinal tumorigenesis. Oncotarget, 7(46), 74427–74434. https://doi.org/10.18632/oncotarget.12769

Readers over time

‘16‘17‘18‘19‘20‘21‘22‘23‘24‘2502468

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 15

68%

Researcher 6

27%

Professor / Associate Prof. 1

5%

Readers' Discipline

Tooltip

Biochemistry, Genetics and Molecular Bi... 14

64%

Agricultural and Biological Sciences 5

23%

Medicine and Dentistry 2

9%

Chemistry 1

5%

Save time finding and organizing research with Mendeley

Sign up for free
0