An improved synthesis of 2-acetamido-2-deoxy-D-gluconohydroximolactone (PUGNAc), a strong inhibitor of β-N-acetylglucosaminidases

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Abstract

O-(2-Acetamido-3,4,6-tri-O-acetyl-D-glucopyranosylidene)amino N- phenylcarbamate (1), an established inhibitor of β-N-acetylglucosaminidases, has been prepared by an improved six-step synthesis from N-acetyl-D- glucosamine.

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Mohan, H., & Vasella, A. (2000). An improved synthesis of 2-acetamido-2-deoxy-D-gluconohydroximolactone (PUGNAc), a strong inhibitor of β-N-acetylglucosaminidases. Helvetica Chimica Acta, 83(1), 114–118. https://doi.org/10.1002/(SICI)1522-2675(20000119)83:1<114::AID-HLCA114>3.0.CO;2-9

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