Folic acid (FA) or biotin-conjugated polyglycerol dendrimers (PGD) that are known to tightly bind to L-arginine (Arg) are explored as possible L-arginine carriers. PGD with generation 3 (PGD-G3) was conjugated with FA or biotin by using a condensation reagent, with a 1:1 stoichiometry. Furthermore, cellular uptake studies suggest that FA or biotin-conjugated PGDs can be used as Arg carriers.
CITATION STYLE
Itakura, Y., & Ooya, T. (2017). Evaluation of ligand-conjugated polyglycerol dendrimers as a L-arginine carrier. Kobunshi Ronbunshu, 74(4), 304–310. https://doi.org/10.1295/koron.2017-0011
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