Methods and Challenges in Investigating Sex-Specific Consequences of Social Stressors in Adolescence in Rats: Is It the Stress or the Social or the Stage of Development?

Abstract

Adolescence is a time of social learning and social restructuring that is accompanied by changes in both the hypothalamic-pituitary-gonadal axis and the hypothalamic-pituitary-adrenal (HPA) axis. The activation of these axes by puberty and stressors, respectively, shapes adolescent development. Models of social stress in rats are used to understand the consequences of perturbations of the social environment for ongoing brain development. This paper reviews the challenges in investigating the sex-specific consequences of social stressors, sex differences in the models of social stress used in rats and the sex-specific effects on behaviour and provides an overview of sex differences in HPA responding to stressors, the variability in pubertal development and in strains of rats that require consideration in conducting such research, and directions for future research.