NF-κB Activation in Airways Modulates Allergic Inflammation but Not Hyperresponsiveness

  • Poynter M
  • Cloots R
  • van Woerkom T
  • et al.
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Abstract

Airways display robust NF-κB activation and represent targets for anti-inflammatory asthma therapies, but the functional importance of NF-κB activation in airway epithelium remains enigmatic. Therefore, transgenic mice were created in which NF-κB activation is repressed specifically in airways (CC10-IκBαSR mice). In response to inhaled Ag, transgenic mice demonstrated significantly ameliorated inflammation, reduced levels of chemokines, T cell cytokines, mucus cell metaplasia, and circulating IgE compared with littermate controls. Despite these findings, Ag-driven airways hyperresponsiveness was not attenuated in CC10-IκBαSR mice. This study clearly demonstrates that airway epithelial NF-κB activation orchestrates Ag-induced inflammation and subsequent adaptive immune responses, but does not contribute to airways hyperresponsiveness, the cardinal feature that underlies asthma.

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APA

Poynter, M. E., Cloots, R., van Woerkom, T., Butnor, K. J., Vacek, P., Taatjes, D. J., … Janssen-Heininger, Y. M. W. (2004). NF-κB Activation in Airways Modulates Allergic Inflammation but Not Hyperresponsiveness. The Journal of Immunology, 173(11), 7003–7009. https://doi.org/10.4049/jimmunol.173.11.7003

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