Carboplatin administration can usually be safely continued via a so-called desensitisation protocol when hypersensitivity reactions arise. Severe break-through reactions that occur early during desensitisation are likely to be IgE-mediated; in that case, addition of omalizumab premedication should be strongly considered.
CITATION STYLE
Oude Elberink, H. N. G., Jalving, M., Dijkstra, H., & Van De Ven, A. A. J. M. (2020). Modified protocol of omalizumab treatment to prevent carboplatin-induced drug hypersensitivity reactions: A case study. Clinical and Translational Allergy, 10(1). https://doi.org/10.1186/s13601-020-0309-0
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