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Stability-Indicating HPTLC-Densitometric Method for Estimation of Dorzolamide Hydrochloride in Eye Drops

  • Havele S
  • Dhaneshwar S
ISRN Analytical Chemistry (2012) 2012 1-7
DOI: 10.5402/2012/414075
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Abstract

The present study describes the degradation of dorzolamide HCl under different International Conference on Harmonization prescribed stress conditions (hydrolysis, oxidation, thermolysis, and photolysis) and application of a specific and selective stability-indicating chromatography assay. HPTLC was done on silica Gel 60 F 254 TLC plate using chloroform: methanol in the ratio of 9.0 : 1.0 (v/v) as mobile phase and detection at 253 nm.

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Havele, S. S., & Dhaneshwar, S. R. (2012). Stability-Indicating HPTLC-Densitometric Method for Estimation of Dorzolamide Hydrochloride in Eye Drops. ISRN Analytical Chemistry, 2012, 1–7. https://doi.org/10.5402/2012/414075

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