Atrial fibrillation (AF) is recognised as the most common sustained cardiac arrhythmia in clinical practice. Ongoing drug development is aiming at obtaining atrial specific effects in order to prevent pro-arrhythmic, devastating ventricular effects. In principle, this is possible due to a different ion channel composition in the atria and ventricles. The present text will review the aetiology of arrhythmias with focus on AF and include a description of cardiac ion channels. Channels that constitute potentially atria-selective targets will be described in details. Specific focus is addressed to the recent discovery that Ca2+-activated small conductance K+ channels (SK channels) are important for the repolarisation of atrial action potentials. Finally, an overview of current pharmacological treatment of AF is included. © 2011 Springer-Verlag Berlin Heidelberg.
CITATION STYLE
Grunnet, M., Bentzen, B. H., Sørensen, U. S., & Diness, J. G. (2012). Cardiac ion channels and mechanisms for protection against atrial fibrillation. Reviews of Physiology, Biochemistry and Pharmacology, 162, 1–58. https://doi.org/10.1007/112_2011_3
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