Benzimidazoles: A biologically active compounds

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Abstract

Synthesis of commercially available benzimidazole involves condensation of o-phenylenediamine with formic acid. The most prominent benzimidazole compound in nature is N-riosyldimethylbenzimidazole, which serves as a axial ligand for cobalt in vitamin B12. The benzimidazole and its derivatives play a very important role as a therapeutic agent e.g. antiulcer and anthelmintic drugs. Apart from this the benzimidazole derivatives exhibit pharmacological activities such as antimicrobial, antiviral, anticancer, anti-inflammatory, analgesic, etc. The substituted benzimidazoles are summarized in this review to know about the chemistry as well as pharmacological activities.

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Salahuddin, Shaharyar, M., & Mazumder, A. (2017, February 1). Benzimidazoles: A biologically active compounds. Arabian Journal of Chemistry. Elsevier B.V. https://doi.org/10.1016/j.arabjc.2012.07.017

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