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Adenosine signaling mediates hypoxic responses in the chronic lymphocytic leukemia microenvironment

  • Serra S
  • Vaisitti T
  • Audrito V
  • et al.
Blood Advances (2016) 1(1) 47-61
DOI: 10.1182/bloodadvances.2016000984
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Abstract

Hypoxia shapes the CLL lymph node microenvironment by acting through the A2A adenosine receptor. Inhibiting the A2A adenosine receptor counteracts the effects of hypoxia on CLL cells, macrophages, and T lymphocytes.

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Serra, S., Vaisitti, T., Audrito, V., Bologna, C., Buonincontri, R., Chen, S.-S., … Deaglio, S. (2016). Adenosine signaling mediates hypoxic responses in the chronic lymphocytic leukemia microenvironment. Blood Advances, 1(1), 47–61. https://doi.org/10.1182/bloodadvances.2016000984

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