Treatment of recurrent paget's disease of the vulva with topical bleomycin

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Abstract

Seven patients with recurrent Paget's disease of the vulva underwent treatment with topical bleomycin (NSC 125066‐Blenoxane®, Bristol Laboratories) ointment. None had an associated invasive carcinoma. Four patients experienced a complete, objective response to this therapy, and one of these has responded completely to treatment of a subsequent recurrence. In two patients the response could not be evaluated. All patients experienced pain in the treated area; one, developed systemic toxicity to bleomycin requiring cessation of therapy. Topical bleomycin appears to benefit selected patients with recurrent Paget's disease of the vulva. Copyright © 1978 American Cancer Society

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Watring, W. G., Roberts, J. A., Lagasse, L. D., Berman, M. L., Ballon, S. C., Moore, J. G., & Schlesinger, R. E. (1978). Treatment of recurrent paget’s disease of the vulva with topical bleomycin. Cancer, 41(1), 10–11. https://doi.org/10.1002/1097-0142(197801)41:1<10::AID-CNCR2820410103>3.0.CO;2-G

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