Fifteen children with atopic dermatitis who had Bifidobacterium-deficient microflora were selected for this study. Eight subjects in the bifidobacteria-administered group were given oral administration of lyophilized bifidobacteria (Bifidobacterium breve M-16V strain). The changes in fecal microflora and clinical symptoms were compared with the control group. In the bifidobacteria-administered group, the proportion of Bifidobacterium in the fecal microflora was increased (P = 0.0173) and the proportion of aerobic bacteria was decreased (P = 0.0499) after 1 month of administration. Furthermore, significant improvement of allergic symptoms (P = 0.0176 in cutaneous symptom score, P = 0.0117 in total allergic score) was also observed in the bifidobacteria-administered group. The tendency of allergic symptom improvement in the bifidobacteria-administered group was remarkable compared with the control group; however there was no correlation between changes in fecal microflora and allergic symptoms.
CITATION STYLE
Hattori, K., Yamamoto, A., Sasai, M., Taniuchi, S., Kojima, T., Kobayashi, Y., … Yaeshima, T. (2003). Effects of administration of Bifidobacteria on fecal microflora and clinical symptoms in infants with atopic dermatitis. Japanese Journal of Allergology, 52(1), 20–30.
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