Magnesium Intake and Risk of Type 2 Diabetes in Men and Women

381Citations
Citations of this article
214Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

OBJECTIVE - To examine the association between magnesium intake and risk of type 2 diabetes. RESEARCH DESIGN AND METHODS - We followed 85,060 women and 42,872 men who had no history of diabetes, cardiovascular disease, or cancer at baseline. Magnesium intake was evaluated using a validated food frequency questionnaire every 2-4 years. After 18 years of follow-up in women and 12 years in men, we documented 4,085 and 1,333 incident cases of type 2 diabetes, respectively. RESULTS - After adjusting for age, BMI, physical activity, family history of diabetes, smoking, alcohol consumption, and history of hypertension and hypercholesterolemia at baseline, the relative risk (RR) of type 2 diabetes was 0.66 (95% CI 0.60-0.73; P for trend <0.001) in women and 0.67 (0.56-0. 80; P for trend <0.001) in men, comparing the highest with the lowest quintile of total magnesium intake. The RRs remained significant after additional adjustment for dietary variables, including glycemic load, polyunsaturated fat, trans fat, cereal fiber, and processed meat in the multivariate models. The inverse association persisted in subgroup analyses according to BMI, physical activity, and family history of diabetes. CONCLUSIONS - Our findings suggest a significant inverse association between magnesium intake and diabetes risk. This study supports the dietary recommendation to increase consumption of major food sources of magnesium, such as whole grains, nuts, and green leafy vegetables.

References Powered by Scopus

Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin

15907Citations
N/AReaders
Get full text

Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus

7720Citations
N/AReaders
Get full text

Global burden of diabetes, 1995-2025: Prevalence, numerical estimates, and projections

5197Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Coffee and health: A review of recent human research

874Citations
N/AReaders
Get full text

Milk nutritional composition and its role in human health

562Citations
N/AReaders
Get full text

Fiber and magnesium intake and incidence of type 2 diabetes: A prospective study and meta-analysis

484Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Lopez-Ridaura, R., Willett, W. C., Rimm, E. B., Liu, S., Stampfer, M. J., Manson, J. E., & Hu, F. B. (2004). Magnesium Intake and Risk of Type 2 Diabetes in Men and Women. Diabetes Care, 27(1), 134–140. https://doi.org/10.2337/diacare.27.1.134

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 73

68%

Researcher 17

16%

Professor / Associate Prof. 11

10%

Lecturer / Post doc 7

6%

Readers' Discipline

Tooltip

Medicine and Dentistry 52

45%

Agricultural and Biological Sciences 31

27%

Nursing and Health Professions 17

15%

Biochemistry, Genetics and Molecular Bi... 15

13%

Article Metrics

Tooltip
Mentions
News Mentions: 2
Social Media
Shares, Likes & Comments: 5

Save time finding and organizing research with Mendeley

Sign up for free