A simple approach for the synthesis of 2,6-diaryl-4-oxo-3,4- dihydropyrimidine-5-carbonitriles

Abstract

A concise, facile and straightforward synthesis of 2,6-diaryl-4-oxo-3,4- dihydropyrimidine-5-carbonitriles 12a-h is reported. The reaction for this preparation involves the condensation of ethyl α-cyanocinnamate and its para substituted analogs 8a-e with arylamidines 9a-d under very mild conditions. A probable mechanism of 12a-h from 11a-h is proposed. A preliminary pharmacological evaluation of compounds 12c, 12d, 12f e 12h has shown that these compounds possess analgesic activity.