Fortimicins A And B, New Aminoglycoside Antibiotics III. Structural Identification

Abstract

The structures of fortimicins A and B have been determined by PMR, CMR, mass spectra and CD combined with chemical degradations. Both antibiotics are pseudodisaccharides and incorporate a novel aminocyclitol, fortamine. Incontrast to the diaminocyclitol moieties of known aminoglycosides, fortamine is a 1,4-diamine, contains both TV- and O-me-thyl groups and possesses chiro stereochemistry. Both antibiotics are glycosides of 6-epl-pur-purosamine B, but fortimicin A differs from fortimicin B by being a glycyl amide. © 1977, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.