A rare case of CD 1a‐negative Langerhans cell histiocytosis of the central nervous system in a child

Abstract

Langerhans cell histiocytosis is a dendritic cell disorder with a wide spectrum of severity and presentations. Histopathology typically demonstrates a proliferation of Langerhans cells and a lymphohistiocytic inflammatory infiltrate with eosinophils. The diagnosis is supported by immunohistochemistry with the cell markers S100, CD 1a, CD 68, and Langerin [ Blood , 126, 2015, 26 and N Engl J Med , 331, 1994, 154].