Accelerated hypo-fractionation by biological equivalent DVH for patients affected by gastric carcinoma in postoperative concomitant radiochemotherapy

Abstract

Recent result of clinical trial on carcinoma of stomach demonstrate an advantage to adjuvant postoperative chemo-radiotherapy witch is now used more commonly for gastric cancer. However remain some doubt for toxicity as for the optimal chemotherapy regimen as for the optimal method of radiation delivery. To increase the biological effectiveness and, at same time, to reduce toxicity of conventional radiotherapy we tested many alternative fractionation schemes of dose radiation, using a biological equivalent Histogram Dose Volume (DVH) for prior analysis and as tool for the assessment and choice of fractionation dose biologically more effective. © 2009 Springer-Verlag.