Cytocompatibility of Ti-6Al-7Nb through high-pressure torsion processing

14Citations
Citations of this article
7Readers
Mendeley users who have this article in their library.

Abstract

In this study, we evaluated the cytocompatibility of high-pressure torsion (HPT)-processed Ti-6Al-7Nb alloys. Grain size of titanium (Ti) alloys decreased from 5 μm (without HPT processing, HPT-0) to ∼100 nm (at 2 GPa, HPT-2) or ∼70 nm (at 6 GPa, HPT-6) through HPT processing. Cell adhesion, proliferation, and differentiation were evaluated with mouse preosteoblast (MC3T3-E1). A locomotion trend was presented by cells cultured on HPT-2 to compare with other specimens, while, an immobilization trend was presented by cells cultured on HPT-6 to compare with other specimens. Akp2 (alkaline phosphatase 2) expression was higher in cells cultured on HPT-2 than that on HPT-0 and HPT-6, indicating enhanced osteogenic differentiation. Our results demonstrate that HPT-processed Ti-6Al-7Nb alloys offer good cytocompatibility.

Cite

CITATION STYLE

APA

Chen, P., Ashida, M., Doi, H., Tsutsumi, Y., Horita, Z., & Hanawa, T. (2016). Cytocompatibility of Ti-6Al-7Nb through high-pressure torsion processing. In Materials Transactions (Vol. 57, pp. 2020–2025). Japan Institute of Metals (JIM). https://doi.org/10.2320/matertrans.MI201515

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free