Characteristic of magnesium substituted octacalcium phosphate prepared by precipitation method

Abstract

Osteoporosis and other bone defect had become major problem worldwide. The main problem is the imbalance between bone formation and bone resorption process. The disproportion of those process leads to bone impairment such as, increase in rigidity and brittleness. This complication could be tackled by adding identical material to the bone at the deficient area. In this case, octacalcium phosphate (OCP) incorporated with magnesium (Mg) shows favorable indication as bone implant or cement. However, the information of the Mg doped OCP was scarce. In this study Mg doped OCP was synthesized by precipitation method to collect uniform sample. As a result, significant change could be observed in the crystal lattice and the particle size. Besides, the existence of Mg alters the stability of the phase transformation during the synthesis. Those properties transformation thus could be further utilized for the Mg doped OCP to be applied clinically.