Echocardiographic Evidence of Left Ventricular Hypertrophy in Obese Dogs

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Abstract

Background: Cardiomyopathy of obesity occurs in humans, but the gross and cellular myocardial response to obesity in dogs is not well defined. Objectives: To characterize in vivo myocardial morphology and function in normotensive obese dogs, and quantitate collagen, triglyceride and myocyte cross-sectional area (CSA) in postmortem tissues from obese dogs. Animals: Echocardiographic-Doppler measurements of normotensive obese dogs (n = 19) without historical or physical examination evidence of disease, and lean healthy dogs (n = 19) matched for age and ideal weight. Postmortem data were obtained from a separate population of 4 obese and 12 lean dogs without evidence of cardiac disease. Methods: A prospective, observational study of myocardial morphology and function was conducted by echocardiographic-Doppler measurement. Left ventricular (LV) tissue was collected for quantitation of triglyceride, collagen, and myocyte CSA. Results: Compared with lean control dogs, obese dogs had increased systolic blood pressure (obese 153 ± 19 mm Hg; lean 133 ± 20 mm Hg; P = .003), and increased LV free wall thickness at end-diastole (obese 9.9 ± 1.8 mm, lean 8.7 ± 1.5 mm; P = .03) and end-systole (obese 15.2 ± 2.3 mm, lean 12.9 ± 2.3 mm; P = .004). Isovolumic relaxation time was prolonged in 7/19 (37%) of obese dogs, compared with normal ranges. Myocardial triglyceride and collagen content and myocyte CSA were similar between groups. Conclusions and Clinical Importance: As in humans, LV hypertrophy and diastolic dysfunction can be an early myocardial change in some obese dogs. © 2012 by the American College of Veterinary Internal Medicine.

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Mehlman, E., Bright, J. M., Jeckel, K., Porsche, C., Veeramachaneni, D. N. R., & Frye, M. (2013). Echocardiographic Evidence of Left Ventricular Hypertrophy in Obese Dogs. Journal of Veterinary Internal Medicine, 27(1), 62–68. https://doi.org/10.1111/jvim.12018

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