An explicit formal-ontological representation of entities existing at multiple levels of granularity is an urgent requirement for biomedical information processing. We discuss some fundamental principles which can form a basis for such a representation. We also comment on some of the implicit treatments of granularity in currently available ontologies and terminologies (GO, FMA, SNOMED CT).
Kumar, A., Smith, B., & Novotny, D. D. (2004). Biomedical informatics and granularity. In Comparative and Functional Genomics (Vol. 5, pp. 501–508). https://doi.org/10.1002/cfg.429