Fas ligand (Fast) and perform pathways not only are the major mechanisms of T cell-mediated cytotoxicity but also are involved in homeostatic regulation of these T cells. In the present study, we tested whether CD8+ donor T cells that are deficient in both perform and FasL (cytotoxic double deficient [cdd]) could induce graft-versus-host disease (GVHD) in a major histocompatibility complex class I-mismatched lethally irradiated murine model. Interestingly, recipients of cdd CD8+ T cells demonstrated significantly greater serum levels of interferon gamma and tumor necrosis factor alpha and histopathologic damage from GVHD than wild-type (wt) T cells on day 30 after allogeneic bone marrow transplantation (P
CITATION STYLE
Maeda, Y., Levy, R. B., Reddy, P., Liu, C., Clouthier, S. G., Teshima, T., & Ferrara, J. L. M. (2005). Both perform and Fas ligand are required for the regulation of alloreactive CD8+ T cells during acute graft-versus-host disease. Blood, 105(5), 2023–2027. https://doi.org/10.1182/blood-2004-08-3036
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