Breaking the diffraction barrier: Super-resolution imaging of cells

Citations of this article
Mendeley users who have this article in their library.


Anyone who has used a light microscope has wished that its resolution could be a little better. Now, after centuries of gradual improvements, fluorescence microscopy has made a quantum leap in its resolving power due, in large part, to advancements over the past several years in a new area of research called super-resolution fluorescence microscopy. In this Primer, we explain the principles of various super-resolution approaches, such as STED, (S)SIM, and STORM/(F)PALM. Then, we describe recent applications of super-resolution microscopy in cells, which demonstrate how these approaches are beginning to provide new insights into cell biology, microbiology, and neurobiology. © 2010 Elsevier Inc.




Huang, B., Babcock, H., & Zhuang, X. (2010, December 23). Breaking the diffraction barrier: Super-resolution imaging of cells. Cell. Cell Press.

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free