In this study we have reported that bergapten (B) and bergapten plus UV (PUVA) are able to significantly affect MCF-7, ZR-75 and SKBR-3 breast cancer cell proliferations.B induced a lowering of PI3K/AKT survival signal in MCF-7 cells even in presence of IGF-I stimulation. Furthermore, B and in a higher extent, PUVA up-regulated the p53 mRNA and the protein content. An increased co-association between p21 WAF and proliferating cell nuclear antigen (PCNA) has been observed in PUVA-treated MCF-7 cells, thus inhibiting DNA replication. These results highlight how B, and its photoactivated compound, exert antiproliferative effects and induce apoptotic responses in breast cancer cells. © 2010 Federation of European Biochemical Societies.
Panno, M. L., Giordano, F., Mastroianni, F., Palma, M. G., Bartella, V., Carpino, A., … Andò, S. (2010). Breast cancer cell survival signal is affected by bergapten combined with an ultraviolet irradiation. FEBS Letters, 584(11), 2321–2326. https://doi.org/10.1016/j.febslet.2010.04.001