An initial loading-dose vitamin D versus placebo after hip fracture surgery: Baseline characteristics of a randomized controlled trial (REVITAHIP)

13Citations
Citations of this article
132Readers
Mendeley users who have this article in their library.

Abstract

Background: Hypovitaminosis D is particularly common among older people with a proximal femoral (hip) fracture. There are currently no agreed strategies for vitamin D replenishment after hip fracture surgery. The REVITAHIP Study is a multisite, double-blinded randomized-controlled trial investigating the effects of an oral vitamin D loading dose on gait velocity after hip fracture surgery. We describe the baseline characteristics of participants, aiming to document hypovitaminosis D and its associations after hip fracture. Methods: Participants, over 65, recruited within 7 days following hip fracture surgery from 3 Australia hospitals, were randomly allocated to receive a loading dose of vitamin D3 (250,000IU) or placebo, followed by oral maintenance vitamin D3/calcium (800 IU/500 mg) and the usual hip fracture rehabilitation pathway. Demographic and clinical data were collected, including surgical procedure, pre-fracture functional status, Mini Mental State Examination (MMSE) score, serum 25-hydroxyvitamin D (25-OHD), Verbal Rating Scale (VRS) for pain, grip strength and gait velocity. The associations of baseline 25-OHD levels with demographic and clinical data were assessed using Pearson's correlation, ANOVA and regression analyses. Results: Two-hundred-and-eighteen people with hip fracture participated in the study. Mean age was 83.9+/-7.2 years, 77% were women and 82% lived in private homes. Fifty-six percent had a subcapital fracture. Mean comorbidity count was 3.13+/-2.0. Mean MMSE was 26.1+/-3.9. Forty-seven percent of participants had hypovitaminosis D (<50 nmol/L). Multivariate regression models demonstrated higher baseline vitamin D levels were significantly associated with higher premorbid Barthel index scores, lower post-operative VRS pain levels and use of vitamin D. Conclusion: This study cohort shared similar demographic characteristics and comorbidities with other cohorts of people with hip fracture, with the probable exception of less cognitive impairment. Hypovitaminosis D was not as prevalent as previously documented. Patients taking vitamin D supplements and with higher premorbid Barthel index, reflecting greater independence and activity, tended to have higher 25-OHD levels at baseline. Further, lower VRS pain ratings following surgery were associated with higher vitamin D levels. Such associations will need further investigation to determine causation. (ANZCTR number, ACTRN12610000392066). Trial registration: The protocol for this study is registered with the Australian New Zealand Clinical Trials Registry ANZCTRN ACTRN12610000392066.

References Powered by Scopus

EuroQol - a new facility for the measurement of health-related quality of life

0
12898Citations
N/AReaders
Get full text

Medical progress: Vitamin D deficiency

11775Citations
N/AReaders
Get full text

The Mini‐Mental State Examination: A Comprehensive Review

4113Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Interventions for preventing falls in older people in care facilities and hospitals

225Citations
N/AReaders
Get full text

Nutritional supplementation for hip fracture aftercare in older people

154Citations
N/AReaders
Get full text

Vitamin D Deficiency and Pain: Clinical Evidence of Low Levels of Vitamin D and Supplementation in Chronic Pain States

76Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Mak, J. C. S., Klein, L. A., Finnegan, T., Mason, R. S., & Cameron, I. D. (2014). An initial loading-dose vitamin D versus placebo after hip fracture surgery: Baseline characteristics of a randomized controlled trial (REVITAHIP). BMC Geriatrics, 14(1). https://doi.org/10.1186/1471-2318-14-101

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 41

68%

Researcher 10

17%

Lecturer / Post doc 6

10%

Professor / Associate Prof. 3

5%

Readers' Discipline

Tooltip

Medicine and Dentistry 42

61%

Nursing and Health Professions 15

22%

Psychology 8

12%

Sports and Recreations 4

6%

Save time finding and organizing research with Mendeley

Sign up for free