The p53 Protein Does Not Facilitate Adenovirus Type 5 Replication in Normal Human Cells

  • Chahal J
  • Flint S
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Abstract

Although several adenovirus type 5 (Ad5) proteins prevent deleterious consequences of activation of p53, it has been reported that viral replication proceeds more efficiently when human tumor cells produce wild-type compared to mutant p53. We have now exploited RNA interference and lentiviral vectors to achieve essentially complete knockdown of p53 in normal human cells: no effects on the kinetics or efficiency of viral gene expression or production of infectious particles were observed.

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Chahal, J. S., & Flint, S. J. (2013). The p53 Protein Does Not Facilitate Adenovirus Type 5 Replication in Normal Human Cells. Journal of Virology, 87(10), 6044–6046. https://doi.org/10.1128/jvi.00129-13

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