Combination of hyperthermia and immunotherapy: Hyperthermia and naïve T-cell therapy

Abstract

Since many of the patients who receive adoptive immunotherapy also receive chemotherapy and/or radiation therapy, evaluation of the curative effect of adoptive immunotherapy itself is difficult. To overcome this, I perform immune monitoring to examine how much individual immunotherapies contribute to the curative effects. As a result, I found that higher whole blood levels of Th1 cytokines prodicing potential may be used to predict better clinical responses. In addition, I showed that the naïve T-cell adoptive therapy, which we developed, has superior clinical efficacy when compared to other immunotherapies. This chapter also describes the results of our clinical trial. In addition, I describe the application of hyperthermia, which can influence the immune-response of a tumor tissue. Basic experiments showed that hyperthermia could be applied to strengthen a patient’s immune system. Next, we performed naïve T-cell adoptive immunotherapy combined with hyperthermia. Finally, I will describe a case of advanced gastric cancer that showed complete remission after treatment with naïve T-cell adoptive immunotherapy combined with hyperthermia.