Combination of hyperthermia and immunotherapy: Hyperthermia and naïve T-cell therapy

0Citations
Citations of this article
2Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Since many of the patients who receive adoptive immunotherapy also receive chemotherapy and/or radiation therapy, evaluation of the curative effect of adoptive immunotherapy itself is difficult. To overcome this, I perform immune monitoring to examine how much individual immunotherapies contribute to the curative effects. As a result, I found that higher whole blood levels of Th1 cytokines prodicing potential may be used to predict better clinical responses. In addition, I showed that the naïve T-cell adoptive therapy, which we developed, has superior clinical efficacy when compared to other immunotherapies. This chapter also describes the results of our clinical trial. In addition, I describe the application of hyperthermia, which can influence the immune-response of a tumor tissue. Basic experiments showed that hyperthermia could be applied to strengthen a patient’s immune system. Next, we performed naïve T-cell adoptive immunotherapy combined with hyperthermia. Finally, I will describe a case of advanced gastric cancer that showed complete remission after treatment with naïve T-cell adoptive immunotherapy combined with hyperthermia.

Cite

CITATION STYLE

APA

Kokura, S. (2016). Combination of hyperthermia and immunotherapy: Hyperthermia and naïve T-cell therapy. In Hyperthermic Oncology from Bench to Bedside (pp. 341–353). Springer Singapore. https://doi.org/10.1007/978-981-10-0719-4_32

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free