Tolevamer is not efficacious in the neutralization of cytotoxin in a human gut model of Clostridium difficile infection

Abstract

The efficacy of tolevamer, a nonantimicrobial styrene derivative toxin-binding agent, in treating simulated Clostridium difficile infection in an in vitro human gut model was investigated. Tolevamer reduced neither the duration nor magnitude of cytotoxin activity by C. difficile, reflecting poor efficacy observed in recent phase III clinical trials. Copyright © 2009, American Society for Microbiology. All Rights Reserved.