A sustainable nano drug delivery system for poorly soluble drug, glipizide: design, in vitro controlled release and kinetics

6Citations
Citations of this article
8Readers
Mendeley users who have this article in their library.

Abstract

The present work deals with the design of drug delivery systems based on 12-tungstophosphoric acid (TPA)-functionalized MCM-48 nanoparticles (TPA/nMCM-48), for poorly soluble drug GLP. Two DDSs, namely GLP loaded on TPA/nMCM-48 and capped by TPA, were designed and characterized by various techniques. An in vitro release study of GLP was carried out in simulated body fluid (pH-7.4, 37 °C) under stirring conditions followed by the evaluation of the release kinetics and mechanism. The release profiles of the designed DDSs were compared with the release profiles of a commercially available formulation (Glynase) and GLP/nMCM-48. The comparison study indicates that TPA acts better as a functionalizing agent rather than as a capping agent and when compared with the marketed formulation, GLP/TPA/nMCM-48 shows more controlled release of GLP with only 15% cytotoxicity.

Cite

CITATION STYLE

APA

Dasgupta, D., & Patel, A. (2022). A sustainable nano drug delivery system for poorly soluble drug, glipizide: design, in vitro controlled release and kinetics. Materials Advances, 3(22), 8220–8228. https://doi.org/10.1039/d2ma00627h

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free