Obstructive Sleep Apnea Is Associated with Altered Glycemic Patterns in Pregnant Women with Obesity

Abstract

Often unrecognized, obstructive sleep apnea (OSA) worsens over pregnancy and is associatedwith poorer perinatal outcomes. The association between OSA in late pregnancy andmetabolic biomarkers remains poorly understood. We tested the hypothesis that OSA in pregnant women with obesity is positively correlated with 24-hour patterns of glycemia and IR despite controlling for diet. Design: Pregnant women (32 to 34 weeks' gestation; body mass index, 30 to 40 kg/m2) wore a continuous glucose monitor for 3 days. OSA was measured in-home by WatchPAT 200 [apnea hypopnea index (AHI), oxygen desaturation index (ODI; number per hour)]. Fasting blood was collected followed by a 2-hour, 75-g, oral glucose tolerance test to measure IR. Association between AHI and 24-hour glucose area under the curve (AUC) was the powered outcome.