Use of Cold Plasma Technology in Biomaterials and Their Potential Utilization in Controlled Administration of Active Substances

Abstract

Currently the controlled supply of drugs or active substances, in biomedical applications, has reached a high scientific and technological interest, mainly due; to the ability to maintain the optimal concentration of an active substance in the desired location, the greatest attention is directed towards biopolymers and bioceramics, due to the various qualities they exhibit such as: biocompatibility, bioactivity, biodegradability, etc. On the other hand, it is well known that the release profile depends crucially on the surface of these biomaterials. To enhance the advantages of the use of these biomaterials in the controlled dosage of drugs, they can be treated by non-thermal plasma, thus improving their surface characteristics (greater functionality and porosity), without altering the integral properties of the biomaterial. The plasma treatment for surface modification of materials is; green, economical, fast and efficient, by varying the parameters in plasma reactors can be adjusted physical and chemical characteristics in treated materials. This review highlights the most recent approaches to the treatment of plasma applied to different biomaterials, which aims to elucidate the outlook that exists regarding its potential application in the area of administration of drugs or active substances, so that this review can be used as a general guide for the selection of future biomaterials treated by plasma with application in controlled dosing.