Microbiome and Human Malignancies

Abstract

Recent technological advances have revolutionized our current understanding of the role of human microbiota in cancer development. Several high-throughput Next Generation sequencing studies including metagenomics and transcriptomics data, along with microarray-based technologies suggest that dysbiosis in the commensal microbiota can initiate a number of inflammatory syndromes as well as multiple cancers in humans. Immune deregulation by the microbial community is considered one of the major contributing factors for cancer development. In this chapter, we broadly discuss recent developments in understanding the interaction of human microbiome and its contribution to cancer, and the possibilities of future diagnostic, as well as potential for development of targeted therapeutics.