A Convenient One-Pot Synthesis of Acyclonucleosides

15Citations
Citations of this article
6Readers
Mendeley users who have this article in their library.

Abstract

Bis(trimethylsilyl)pyrimidine bases were treated directly with 1,3-dioxolane (or 2-methyl- 1,3-dioxolane), chlorotrimethylsilane and a metal iodide, such as KI or Nal, in acetonitrile at room temperature to afford acyclopyrimidine derivatives, including 2-thiopyrimidine derivatives, in good yields. Introduction of an acyclic chain into 2-thiopyrimidine bases, however, necessitated the use of 2 eq of the reagents. © 1995, The Pharmaceutical Society of Japan. All rights reserved.

Cite

CITATION STYLE

APA

Ubasawa, M., Takashima, H., & Sekiya, K. (1995). A Convenient One-Pot Synthesis of Acyclonucleosides. Chemical and Pharmaceutical Bulletin, 43(1), 142–143. https://doi.org/10.1248/cpb.43.142

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free