Chronotype and sleep quality assessment of patients with polycystic ovary syndrome

Abstract

Aim: Polycystic Ovary Syndrome (PCOS) is the most common endocrine disorder among women during the reproductive ages. The purpose of this study was to investigate the chronotype and sleep quality of PCOS patients. Methods: Volunteering nulliparous participants who were diagnosed with PCOS and a convenience sample of healthy controls without accompanying chronic medical conditions who presented to the Bezmialem University gynecology outpatient clinic were enrolled in the study. Participants were asked to fill out the Turkish versions of Morningness Eveningness Questionnaire (MEQ) and Pittsburgh Sleep Quality index Questionnaire (PSQIQ). Results: There were 111 participants in the PCOS group and 108 participants in the healthy control group. Both groups were similar in age (p=0.24) and body mass index (p=0.9). The prevalance of hirsutism (mFG ≥8) was 33.3% among PCOS patients. Subjective sleep quality (<0.001), sleep latency (<0.001), habitual sleep efficiency (0.003), utilization of sleep medication (0.03) and daytime dysfunction (<0.001) scores were significantly different between the groups. In the PCOS group, MEQ score was inversely correlated with the mFG score and fT levels. There was a negative correlation between MEQ-mFG (r=-0.59, p<0.001). Conclusion: PCOS patients were more prone to eveningness chronotype and had worse sleep quality compared to controls. Furthermore PCOS patients with hirsutism were more evening oriented and had more difficulty falling asleep compared to those without hyperandrogenism.