Electro Spun-Nanofibrous Mats: A Modern Wound Dressing Matrix with a Potential of Drug Delivery and Therapeutics

Abstract

Nanofibers have emerged as advanced fibers with broad use and potential in biomedical fields in recent decades. The process of healing is an innate immune response towards a pathophysiology such as wound. Ordinary time taken for wound healing is approximately 2-3 days depending upon the chronic state. Air moisture and microbes risk pathological manifestations leading to delayed or incomplete palliate process. An external agent that can provide balanced moisture, increasing cell proliferation with microbial infiltration or anti-bacterial activity, aids to speed the healing process. Apart from these qualities, an ideal material should be simple, cost effective, and repeatable. Nanofibers produced through electrospinning have become a promising strategy in the treatment of wounds. Apart from being simple in application, they are produced from natural or synthetic polymers. Nanofibers exhibit high surface area, nanoporosity, with a potential to load potent drugs or enzymes. Other biomedical applications include use of nanofibers as tissue scaffolds and as masking agents in modern cosmetics. Therefore nanofibers are excellent candidates for wound treatment and management. The current review is an attempt to discuss and present literature about different techniques, chemical materials, and entities used to produce efficient electrospun nanofibers for use in pathological, medicinal, or treatment or management of injury or laceration.