Fusidic acid resistance in community isolates of methicillin-susceptible Staphylococcus aureus and fusidic acid prescribing

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Abstract

The level of resistance to fusidic acid among community methicillin-susceptible Staphylococcus aureus (MSSA) isolates in the UK and prescriptions for fusidic acid have both doubled over the past 6 years. It is hypothesized that selective pressure arising from topical use of fusidic acid in the community accounts for this increase. A significant correlation was found between prescribing of fusidic acid and resistance at the practice level (Spearman's rho = 0.46, 95% confidence interval 0.11-0.71, P=0.01). Further controlled studies are required to determine whether this association is causal.

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Mason, B. W., Howard, A. J., & Magee, J. T. (2003). Fusidic acid resistance in community isolates of methicillin-susceptible Staphylococcus aureus and fusidic acid prescribing. Journal of Antimicrobial Chemotherapy, 51(4), 1033–1036. https://doi.org/10.1093/jac/dkg190

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