A Systematic Review of Procyanidins: Updates on Current Bioactivities and Potential Benefits in Wound Healing

Abstract

Introduction: Procyanidins are a class of flavonoids found in many fruits and plants and have been used as traditional medicine or other homemade remedies, particularly for wound healing. This study systematically reviews the available literature on the potential benefits of procyanidins for wound healing in human cells. Materials/Methods: Relevant keywords consisting of "Procyanidin" AND "Wound healing" was explored in databases including PubMed, Google Scholar, Nature, and Science Direct. This is a systematic review following the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Results: Seven (7) articles met the established inclusion and exclusion criteria. Procyanidins presented a potential benefit in cellular proliferation and migration, antibacterial, anti-inflammatory, and antioxidant activity in wound healing. Conclusion: Procyanidins are beneficial for developing therapies in wound healing, and our review provides a scientific basis for future research.