The use of ion-mobility spectrometry (IMS) coupled to mass spectrometry (IMS-MS) for biomol. analyses has steadily increased over the past two decades, and is now applied to both proteomic and metabolomic investigations. This chapter describes the application of traveling-wave ion-mobility spectrometry-mass spectrometry (TWIMS-MS) to the anal. of a selection of bioactive phytochems. used in dietary supplements. Applications include the anal. of grape seed proanthocyanidins and the structural characterization of bioactive constituents of dietary supplements using TWIMS-MS in conjunction with tandem mass spectrometry. We also discussed is the application of TWIMS-MS for the gas-phase mobility sepn. of structural isomers and the estn. of collision cross sections for a small selection of phenolic compds. from hop Recent applications of IMS-MS to a broad range of biomol. measurements have demonstrated that IMS-MS has emerged as a powerful anal. technique capable of providing the sepn. space necessary to analyze highly complex samples. We give a perspective on emerging applications of IMS-MS for small mol. and biopolymer applications.The combination of devices that allow real-time monitoring of living systems using IMS-MS is an exciting avenue of facilitating system-biol. expts. The future of IMS-MS is bright and full of opportunities. [on SciFinder(R)]
CITATION STYLE
Maier, C. S., Zandkarimi, F., Wickramasekara, S., Morre, J., & Stevens, J. F. (2013). Electrospray Ionization Traveling Wave Ion Mobility Spectrometry Mass Spectrometry for the Analysis of Plant Phenolics: An Approach for Separation of Regioisomers. In 50 Years of Phytochemistry Research (pp. 21–41). Springer International Publishing. https://doi.org/10.1007/978-3-319-00581-2_2
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