Design and synthesis of new 6-nitro and 6-Amino-3,3a,4,5-Tetrahydro-2H-Benzo[g]indazole derivatives: Antiproliferative and antibacterial activity

2Citations
Citations of this article
15Readers
Mendeley users who have this article in their library.

Abstract

New substituted benzo[g]indazoles functionalized with a 6-nitro and 6-amino groups have been synthesized by the reaction of benzylidene tetralones with hydrazine in acetic acid. The resulting conformationally-constrained compounds were evaluated for their antiproliferative activity against selected cancer cell lines. The nitro-based indazoles 11a, 11b, 12a and 12b have shown IC50 values between 5-15 μM against the lung carcinoma cell line NCI-H460. Moreover, the nitro compounds were tested for antibacterial activity where compounds 12a and 13b have shown MIC values of 250 and 62.5 μg/mL against N. gonorrhoeae with no hemolytic activity in human red blood cells (RBC).

Cite

CITATION STYLE

APA

Cuartas, V., Crespo, M. D. P., Priego, E. M., Persoons, L., Daelemans, D., Camarasa, M. J., … Pérez-Pérez, M. J. (2019). Design and synthesis of new 6-nitro and 6-Amino-3,3a,4,5-Tetrahydro-2H-Benzo[g]indazole derivatives: Antiproliferative and antibacterial activity. Molecules, 24(23). https://doi.org/10.3390/molecules24234236

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free