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Longitudinal variation in O6-alkylguanine DNA-alkyltransferase activity in the human colon and rectum

British Journal of Cancer (2002) 87(2) 168-170
DOI: 10.1038/sj.bjc.6600455
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Abstract

In a systematic study of O6-alkylguanine DNA-alkyltransferase activity in the human colon and rectum, tumours were found to occur in regions of low activity. These results are consistent with the hypothesis that O6-alkylguanine DNA-alkytransferase levels and alkylating agent exposure may be important determinants of large bowel tumorigenesis. © 2002 Cancer Research UK.

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Lees, N. P., Harrison, K. L., Hill, E., Hall, C. N., Margison, G. P., & Povey, A. C. (2002). Longitudinal variation in O6-alkylguanine DNA-alkyltransferase activity in the human colon and rectum. British Journal of Cancer, 87(2), 168–170. https://doi.org/10.1038/sj.bjc.6600455

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