Asymmetric Hydrogenation

Abstract

A review. This review described the application of chiral organometallic catalysts for the enantioselective (transfer) hydrogenation of C:C, C:O, and C:N bonds in the fine chems. industry. Covered are processes that were and/or are presently used for the com. manuf. of chiral compds. as well as selected pilot and bench-scale processes not (yet) used in prodn. The review was organized according to the metal precursor actually employed in the hydrogenation reactions. Described are large scale applications of Rh, Ru, and Ir complexes with chiral P-P, P-N and N-N ligands, either used as preformed, isolated complexes or as in situ-prepd. catalyst precursors. [on SciFinder(R)]