The consolidation and compaction behaviour of sieve fractions of crystalline α-lactose monohydrate were studied. From mercury porosimetry measurements tablet pore surface areas were derived. At a certain compaction load it appeared that tablets compressed from small particles were generally stronger and showed a larger surface area than compacts prepared from coarse sieve fractions. By plotting compact strength against pore surface area, a unique linear relationship was obtained. From these results it can be concluded that the actual tablet surface area, being a function of both the initial particle size and applied compaction pressure, is responsible for the compact strength. © 1986 Bohn, Scheltema & Holkema.
CITATION STYLE
De Boer, A. H., Vromans, H., Leur, C. F., Bolhuis, G. K., Kussendrager, K. D., & Bosch, H. (1986). Studies on tableting properties of lactose - Part III. The consolidation behaviour of sieve fractions of crystalline α-lactose monohydrate. Pharmaceutisch Weekblad Scientific Edition, 8(2), 145–150. https://doi.org/10.1007/BF02086149
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