Effects of Vitamin D3 and resveratrol on learning and memory disabilities of streptozotocin-induced diabetic mice

Abstract

This study was conducted for investigating the effects of chronically administered vitamin D3 and resveratrol, which has antioxidant properties, on memory and learning impairment caused by streptozotocin-induced diabetes. Saline was administered to the mice in the first group. Streptozotocin (60 mg/kg, i.p.) was given to the mice in the second group for 3 consecutive days and no treatment was performed. Vitamin D3 (800 IU/kg, i.p.) was given to the streptozotocin-induced hyperglycemic mice in the third group for 4 weeks. Resveratrol (40 mg/kg, i.p.) was given to the streptozotocin-induced hyperglycemic mice in the fourth group for 4 weeks. Then, the passive avoidance test was applied to the mice. A significant difference was found between DM+Vit D3 group (21.6 ± 1.7, n = 7) and diabetic control group (28 ± 2.6, n = 7) in the acquisition test (p < 0.001). A similar result was observed between diabetic-resveratrol group (23.7 ± 2.5, n = 7) and the untreated diabetic mice group (28 ± 2.6, n = 7). There was a significant difference. 4-week vitamin D3 (400 IU/day, i.p.) and 4-week resveratrol (40 mg/kg, i.p.) treatments given to streptozotocin-induced diabetic mice were observed to significantly improved the passive avoidance acquisition and retention times. These results show the positive effects of vitamin D3 on memory.