Pinazepam (P) (10 mg) was orally administered to two young (22-23 years) and two elderly (74-80 years) healthy volunteers. Also, desmethyldiazepam (DD) (10 mg) was orally administered to the same young volunteers on a separate occasion. P was almost completely converted into DD 24 h after administration. Plasma levels of DD were measured in all subjects. In all cases, the DD concentration-time curve showed a biphasic decay (a first slow decay was followed by a fast one) which closely fitted by a Michaelis-Menten equation. Vmax and km constant were computed for all subjects. The kinetic analysis relative to the young subjects showed that T 1/2 of both the slow and fast decay as well as the area under the curve (AUC) were reduced when P was administered instead of DD. Comparison of DD kinetics between young and elderly subjects showed an increase of half-life in the elderly, while AUC was found unchanged. © 1982 Springer-Verlag.
CITATION STYLE
Pacifici, G. M., Cuoci, L., Placidi, G. F., Fornaro, P., & Gomeni, R. (1982). Elimination kinetics of desmethyldiazepam in two young and two elderlysubjects. European Journal of Drug Metabolism and Pharmacokinetics, 7(1), 69–72. https://doi.org/10.1007/BF03189546
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