SP021RENAL SURVIVAL AND ASSOCIATED FACTORS IN PATIENTS WITH AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE

Abstract

Introduction and Aims: In this study, we investigated the renal survival and the associated factors in patients with autosomal dominant polycystic kidney disease (ADPKD). Methods: Demographic (age, gender, family history), clinical and laboratory findings (mean arterial pressure, serum creatinine, albumin, calcium, phosphorus, CRP, Hb, creatinine clearance, amount of proteinuria), conditions associated with disease (macroscopic hematuria, renal stone, hernia, extrarenal cysts, intracranial aneurysm, mitral valve prolapse, diverticular disease of the colon, urinary tract infection), presence of diabetes, hypertension and antihypertensive treatment (usage of ACE-i or ARB and others) of ADPKD patients who were followed up between January 1990 - January 2015 were recorded from patient files retrospectively. ESRD was defined as creatinine clearance ≤ 15 ml/min/1.73 m2. Demographic, clinical, laboratory and treatment findings were compared between ESRD patients and non-ESRD patients for determination of factors associated with renal survival. Statistical analysis was performed using Student's t-test, Chi-square test, Kaplan-Meier survival analysis, log-rank test, cox-regression and logistic regression analysis. Results: 300 patients with ADPKD (157 F, 143 M) were evaluated (Table 1). 115 patients developed ESRD during follow-up. The factors associated with renal survival were shown in Table 2. Diagnosed at a younger age, female gender, high creatinine clearance level at initial admission and the use of ACE-i or ARB were found as significant factors for increased renal survival. Presence of macroscopic hematuria, hypertension and ischemic heart disease and proteinuria level were found as significant factors for decreased renal survival. Conclusions: The use of ACE-i or ARB was found as a modifiable factor for improvement of renal survival in ADPKD patients with hypertension. (Table Presented).