Quantitative estimation of mechanical and optical properties from ultrasound assisted optical tomography data

Abstract

We demonstrate quantitative optical property and elastic property imaging from ultrasound assisted optical tomography data. The measurements, which are modulation depth M and φ . of the speckle pattern, are shown to be sensitively dependent on these properties of the object in the insonified focal region of the ultrasound (US) transducer. We demonstrate that Young fs modulus (E) can be recovered from the resonance observed in M versus ω (the US frequency) plots and optical absorption (μa) and scattering (μs) coefficients from the measured differential phase changes. All experimental observations are verified also using Monte Carlo simulations. © 2012 Society of Photo-Optical Instrumentation Engineers (SPIE).